50 CENT'S BABY MAMA #1 HE HASN'T SEEN HIS TEENAGE SON IN 2 YEARS

50 Cent's teenage son feels like he's been replaced by the rapper's new baby -- saying he hasn't seen his dad in nearly two years ... in fact, he didn't even know he had a half-brother until the story broke.

Marquise Jackson's mother Shaniqua Tompkins in an interview said that, the last time 50 Cent saw 17-year-old Marquise was May 2012, several months before 50's second child Sire Jackson was born.

The fight stemmed from a botched visitation attempt -- 50 claimed he showed up to Marquise's house in Atlanta to visit, but Marquise refused to answer the door, and the texts that followed were brutal ... including messages like, "F**k you stop texting me" and "I don't have a son anymore."Now Marquise feels abandoned ... because 50 is showering Sire with attention and hasn't bothered to reach out to Marquise.

50's, rep tells that, "50 is saddened by the attention-seeking tactics of his son's mother.  He remains a proud and supportive father and feels blessed to have two sons."  A source connected to 50 says the woman hasn't worked since 2002 and this is ultimately a money grab.

50 recently posted doting photos of Sire on Instagram, but quickly removed them out of concern for Sire's safety.